Question
Explain the following giving one example for each:
(i) Reimer-Tiemann reaction.
(ii) Friedel Craft’s acetylation of anisole.
Solution
i) Reimer-Tiemann Reaction: Reimer-Tiemann reaction involves the treatment of phenol with chloroform in the presence of aqueous sodium hydroxide at 340 K followed by hydrolysis of the resulting product to give 2-hydroxybenzaldehyde (salicylaldehyde). The chemical reaction can be represented as follows.
ii) Friedel-Crafts acetylation of anisole: Friedel-Crafts acetylation of anisole involves the treatment of anisole with either acetyl chloride or acetic anhydride to give 2-methoxyacetophenone (as a minor product) and 4-methoxyacetophenone (as a major product).
The chemical reaction can be represented as follows.
