Molecular Basis of Inheritance

Question

Describe briefly the mechanism of DNA replication.

Answer

Replication is the process by which DNA copies itself.
Mechanism of DNA replication
1. It starts at a specific point called the origin. Bacterial and viral DNA have single origin whereas eukaryotic DNA has many origins.
2. The two strands of the DNA double helix unwind in some regions and form replication fork.
The DNA polymerases attach and start polymerizing the DNA in a 5'-3' direction . Thus on one strand the polymerisation is continuous and in the other it is discontinuos in the form of short fragments called Okazakki fragments which is later joined by enzyme DNA Ligase.





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