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Molecular Basis Of Inheritance

Question
CBSEENBI12002617

Sickle cell anaemia is

  • an autosomal-linked dominant trait

  • caused by substitution of valine by glutamic acid in the β-globin chain of haemoglobin

  • caused by a change in a base pair of DNA

  • characterised by elongated sickle-like RBCs with a nucleus

Solution

C.

caused by a change in a base pair of DNA

Sickle-cell anaemia is caused by a change in a single base DNA. It is genetic disease reported from negroes. The individuals of stickle-cell anaemia are immune to malaria.