Sponsor Area

Molecular Basis Of Inheritance

Question
CBSEENBI12001894

How are the structural genes activated in the lac operon in E.coli

Solution
The Lac operon in E.coli  consists of  one regulatory gene (the i gene ) and three structural genes (z, y, and a).Lactose acts as the inducer and it regulates switching on and off of the operon. The i gene produces repressor all-the-time (constitutively) which inactivates the structural gene.The repressor protein binds to the operator region of the operon and prevents RNA polymerase from transcribing the operon. Lactose inactivates the repressor allowing the  RNA polymerase access to the promoter and transcription proceeds. The structural genes are activated and transcribed.