(a) Sickle celled anaemia in humans is a result of point mutation. Explain.

(b) Write the genotypes of both the parents who have produced a sickle celled anaemic offspring.

Solution

(a) Sickle cell anaemia in humans is a result of point mutation because a single base change in the gene for beta globin chain results in the change of amino acid residue glutamate to valine leads to the replacement of GAG by GUG codon at sixth position.

(b) Genotypes of parents who have produced a sickle celled anaemic offspring can be either

Hb^A/ Hb^s and Hb^A/ Hb^s

or, Hb^s/ Hb^s and Hb^A/ Hb^s

Some More Questions From Principles of Inheritance and Variation Chapter

Mention the phenomenon of pleiotropy by giving an example.

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Principles Of Inheritance And Variation

(a) Sickle celled anaemia in humans is a result of point mutation. Explain.

(b) Write the genotypes of both the parents who have produced a sickle celled anaemic offspring.

Some More Questions From Principles of Inheritance and Variation Chapter

Mention the phenomenon of pleiotropy by giving an example.

Name the plant that shows incomplete dominance in respect of the colour of its flower.

Write the genotypes of man with blood group A.

What is Mendel’s monohybrid phenotypic ratio ?

Write down Mendel’s dihybrid Phenotypic ratio

Who were the rediscoverers of Mendelism ?

What are the real determinants of what an organism will become ?

What is the unique feature of F1 generation ?

What will be the genetic make up of an organism which suffers from sickle cell anaemia ?

What do the symbols square and circle in a pedigree chart indicate ?

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NCERT Sample Papers

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For Daily Free Study Material Join wiredfaculty

Principles Of Inheritance And Variation

(a) Sickle celled anaemia in humans is a result of point mutation. Explain. (b) Write the genotypes of both the parents who have produced a sickle celled anaemic offspring.

Some More Questions From Principles of Inheritance and Variation Chapter

Mention the phenomenon of pleiotropy by giving an example.

Name the plant that shows incomplete dominance in respect of the colour of its flower.

Write the genotypes of man with blood group A.

What is Mendel’s monohybrid phenotypic ratio ?

Write down Mendel’s dihybrid Phenotypic ratio

Who were the rediscoverers of Mendelism ?

What are the real determinants of what an organism will become ?

What is the unique feature of F1 generation ?

What will be the genetic make up of an organism which suffers from sickle cell anaemia ?

What do the symbols square and circle in a pedigree chart indicate ?

Mock Test Series

NCERT Sample Papers

Entrance Exams Preparation

(a) Sickle celled anaemia in humans is a result of point mutation. Explain.

(b) Write the genotypes of both the parents who have produced a sickle celled anaemic offspring.