Sponsor Area

Human Health And Disease

Question
CBSEENBI12001715

Write the function of adenosine deaminase enzyme. State the cause of ADA deficiency in humans. Mention a possible permanent cure for ADA deficiency patient.

Solution

Adenosine deaminase enzyme is very important for the functioning of immune system. ADA deficiency is due to deletion of the gene for adenosine deaminase.

Possible permanent cure for the deficiency is gene therapy. In gene therapy the lymphocytes from the blood of the patients are grown in a culture outside the body. Then a functional ADA cDNA using a retroviral vector is introduced into the cultured lymphocytes. The lymphocytes are then returned to the patient’s body. If the genes isolated from the bone marrow cells producing ADA is introduced into the cells at an early embryonic stage the cure can be permanent.