Question
How insulin is synthesised in human (or mammals) . Give a suitable diagram?
Solution
Synthesis of insulin in humans-:
i. Insulin is synthesised as an inactive form pro-insulin which contains an extra stretch called the C peptide.
ii.This pro-insulin is cleaved.
iii. C-peptide is removed and
iv. The two chains A and B are joined by disulfide bridges to form mature insulin.
Fig.- Proinsulin which contain C-peptide is cleaved and C-peptide is removed and the Two chains A and B are joined to by disulfide bridges to form insulin.
