Differentiate Leading Strand and Lagging Strand.

Solution

Differences between a leading strand and a lagging strand

Leading Strand

Lagging Strand

1. The replication on this strand is continuous.

2. DNA ligase is not required

3. It is synthesized in the 5’ → 3’ direction.

1. The replication on this strand is discontinuous in the
form of short Okazaki fragments.

2. DNA ligase enzyme is required for joining Okazaki fragments.

3. In Okazaki fragments direction is 5’ → 3’ but overall direction is 3’ → 5’.

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