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Molecular Basis Of Inheritance

Question
CBSEENBI12000351
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Describe Griffith’s experiment to demonstrate that DNA is the basic genetic material.  What observation was given by Avery, McCarty and MacCleod?

Solution

Griffith’s experiment  demonstrated DNA as genetic material. 
His experiment involved the following steps
1. He grew Streptococcus pneumoniae (pneumococcus) bacteria on culture plates,  some produce smooth shiny colonies (S) because of the mucous coat while othersproduce rough colonies (R).
2.When he infected mice with the S strain (virulent) they died from pneumonia infection but mice infected with the R strain did not.
3.He killed bacteria by heating and observed that heat-killed S strain bacteria did not kill the mice. But when he injected the mice with heat-killed S strain and live R strain then the mice dies.
Thus he concluded that transformation of R-strain into S-strain was due to the transfer of genetic material.



Avery, MacCleod and McCarty showed that the“transforming agent” is DNA. 

 

 

Some More Questions From Molecular Basis of Inheritance Chapter

List the function of RNA.

List the number of base pairs in :

(i) lambda bacteriophage

(ii) E.coli and

(iii) haploid content of human DNA.

Comment two chains of DNA have antiparallel polarity.

What is the difference between DNAs and DNAase ?

Which was first genetic material ?

Suggest one evidence to prove that RNA was first genetic material.

Why was RNA unstable ?

What made DNA more preferrable as genetic material ?

Process of replication is completed in how much time in E.coli ?

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