Sponsor Area

Molecular Basis Of Inheritance

Question
CBSEENBI12000297

(a) How did the transformation experiments of Griffith differ from those of Avery and MacCleod ?

(b) What was the significance of each ?

Solution
(a) Griffith’s in vivo experiments demonstrated the occurrence of transformation in Pneumococcus. They provide no indication as to molecular basis of the transformation phenomenon. Avery and MacCleod carried their experiments in vitro employing biochemical analysis to demonstrate that transformation was mediated by DNA

(b) Griffith showed that a transforming substance existed whereas Avery, MacLeod and McCarty proved that it is DNA.