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Molecular Basis Of Inheritance

Question
CBSEENBI12003210

During transcription holoenzyme RNA polymerase binds to a DNA sequence and the DNA assumes a saddle like structure at that point. What is that sequence called?

  • CAAT box

  • GGTT box

  • AAAT box

  • TATA box

Solution

D.

TATA box

TATA box is present in eukaryotic promoter region. It has a resemblance with pribnow box of prokaryotes. TATA box was identified by Dr. Hogness and so, it is also called as Hogness box. It is a 7 bp long region located 20 bp upstream to the start point. During the process of transcription, the RNA polymerase (a holoenzyme which has a core unit and a sigma factor for proper initiation of transcription) binds to TATA box due to which DNA assumes a saddle like structure at this place.