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Principles Of Inheritance And Variation

Question
CBSEENBI12046984
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The 'cri-du-chat' syndrome is caused by change in chromosome structure involving

  • deletion

  • duplication

  • inversion

  • translocation

Solution

A.

deletion

Cri du chat is a rare syndrome caused by a deletion on the short arm of chromosome 5. It is a rare genetic disorder due to a missing portion of chromosome 5. It refers to a distinctive cry of children. The cry is mainly caused by abnormal larynx development, which becomes normal within a few weeks of birth. Infants with cri du chat have low birth weight and may have respiratory problems.

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