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Human Health And Disease

Question
CBSEENBI12046965
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An insect bite may result in inflammation of that spot. This is triggered by the alarm chemicals such as

  • histamine and dopamine

  • histamine and kinins

  • interferons and opsonin

  • interferons and histones

Solution

B.

histamine and kinins

Inflammation is a process by which body's immune system malfunctions. It is common to almost all diseases that involve microbiologic, chemical or physical injury to living tissues. Acute inflammation is a short term process occuring in response to tissue injury. Heat, Redness, Pain, swelling and loss of function are the cardinal signs. 

Histamine is stored in mast cell granules and basophils. It is released by inflammatory and immunologic stimuli. It plays an important role in acute inflammation, exerting a dilator action on arterioles, increasing the permeability of small venules to plasma proteins and causing pain by stimulating nociceptors. 

Plasma kinins such as bradykinin are not stored but are released by the action of kininogenase on plasma a,­ globulin. Bradykinin is a potent vasodilator, increasing small vein permeability and causing pain by stimulating peripheral nociceptors, but it has a short half-life.

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