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Human Health And Disease

Question
CBSEENBI12047477
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Guillain Base syndrome is an autoimmune disease in humans. In this disease, antibodies are produced against.

  • TSH receptor on thyroid cells

  • Pancreatic beta cell antigen

  • Acetylcholine receptor of motor endplate

  • Myelin of peripheral nerves

Solution

D.

Myelin of peripheral nerves

The lack of immune response by lymphocytes to cells of the body is known as self-tolerance and appears to be due to the elimination of self-reactive lymphocytes by clonal deletion.

When self-toterance fails the body makes antibodies against its own components through T-cell activated B-lymphocytes. The body attack its own cells. leads to autoimmune diseases. Guillain Barre syndrome is acute inflammatory demyelina- ting polyneuropathy in which myelin of peripheral nerves is affected.

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