Select the correct combination of statements regarding Myasthenia gravis.
I. It is an autoimmune disorder.
II. It causes insufficient acetylcholine binding that affects muscular contraction.
III. Antibodies are developed against acetylcholine
IV. Antibodies are developed against acetylcholine receptors.
V. Antibodies are developed against acetylcholine esterase.
VI. It causes drooping of eyelids.

I, III, IV, VI

I, II, IV, VI

I, II, IV, VI

II, III, IV, V

Solution

I, II, IV, VI

Myasthenia gravis is an autoimmune neuromuscular disease or congentital. It is caused by circulating antibodies that block acetylcholene receptors at the post-synaptic neuromuscular junction inhibiting the excitatory effects of acetyl choline and nicotinic receptors at neuromuscular junctions. It has following symptoms-

(i) leads to muscle weakness.

(ii) weakning of eye muscles leading to drooping of eyelids.

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