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Principles Of Inheritance And Variation

Question
CBSEENBI12047355

If both parents are carriers for thalassemia, which is an autosomal recessive disorder, what are the chances of pregnancy resulting in an affected child?

  • No chance

  • 50%

  • 25%

  • 100%

Solution

C.

25%

Thalassemia is the disorder due to reduced synthesis of either the α or β- chains, likewise designated as α or β- thalassemias. When this autosomal mutant gene is present in double dose, it is known as thalassemia major.