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Molecular Basis Of Inheritance

Question
CBSEENBI12047263

Out of A-T, G-C pairing, bases of DNA may exist in alternate valency state owing to arrangement called

  • tautomerisational mutation

  • analogue substitution

  • point mutation

  • frameshift mutation

Solution

A.

tautomerisational mutation

In the early 1950s, guanine and thymine were generally portrayed in the enol form, although there was little data to support the predominance of one form over the other. James Watson and Francis Crick discovered that by using the keto forms instead of the enol forms, they could 'form' two base pairs, an adenine thymine pair and a guanine-cytosine pair, that had the same overall size and shape. These base pairs formed the basis for Watson and Crick's model of DNA.

The process of changing keto form in to enol form of a given organic compound is known as tautomerisational mutation.