The most abundant intracellular cation is
Na+
Ca2+
H+
K+
D.
K+
The most abundant cation or positively charged ion in the extracellular fluid (ECF) is sodium (Na+). The most abundant anion or negatively charged ion in the ECF is chloride (Cl-). The most abundant cation in the intracellular fluid (ICF) is potassium (K+). Ca2+ plays an important role in signal transduction pathways. H+ is found in aqueous solution of all acids.