Absorption of vitamin-B;» in human requires 'P' glycoprotein secreted from 'Q'. The correct choices of P and Q are
P - Extrinsic factor; Q - Stomach
P - Intrinsic factor; Q - Stomach
P - Intrinsic factor; Q - Small intestine
P - Exopolysaccharide; Q - Small Intestine
B.
P - Intrinsic factor; Q - Stomach
Intrinsic Factor (IF) also known as gastric Intrinsic Factor (GIF), is a glycoprotein produced by the parietal cells of the stomach. It is present in the gastric juice as well as gastric mucous membrane.
Upon entry into the stomach, vitamin-B12 becomes bound to haptocorrin (a glycoprotein.) The resulting complex enters the duodenum, where pancreatic enzymes digest haptocorrin. In the less acidic environment of the small intestine, B12 can then bind to intrinsic factor.
