Question
The enzyme hexokinase which catalysis glucose to a glucose-6-phosphate in glycolysis is inhibited by glucose-6-phosphate. This is an example of
I. Competitive inhibition
II. non-competitive inhibition
III. feedback allosteric inhibition
Which of the above statements is/are correct?
I and II
I and III
Only III
All of these
Solution
C.
Only III
Hexokinase catalyses the phosphorylation of hexose in general and is found in all cells that metabolise glucose. It has low Km (high affinity, strong bonding) with glucose in such a way that it is active at low glucose concentration. It shows allosteric feed beat inhibition by to product glucose-6-phosphate.
