Question
Anaphase promoting complex (APC) is a protein degradation machinery necessary for proper mitosis of animal cells. If APC is defective in a human cell, which of the following is expected to occur?
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Chromosomes will not condense
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Chromosomes will be fragmented
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Chromosomes will not segregate
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Recombination of chromosome arms will occur
Solution
C.
Chromosomes will not segregate
Anaphase Promoting Complex (APC) is a protein necessary for separation of daughter chromosomes during anaphase. If APC is defective then the chromosomes will fail to segregate during anaphase.