The chemiosmotic coupling hypothesis of oxidative phosphorylation proposes that Adenosine Triphosphate (ATP) is formed because
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High energy bonds are formed in mitochondrial proteins
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ADP is pumped out of the matrix into the intermembrane space
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a proton gradient forms across the inner membrane
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there is a change in the permeability of the inner mitochondrial membrane toward Adenosine Diphosphate (ADP)
C.
a proton gradient forms across the inner membrane
The production of ATP with the help of energy liberated during oxidation of reduced coenzymes and terminal oxidation is called oxidative phosphorylation. Peter Mitchell (1961) put forward a hypothesis known as a chemiosmotic hypothesis for ATP synthesis. According to this when electrons flow from dual proton, electron carrier to a non-hydrogen carrier the H+ in the intermembranous space than the matrix. Due to proton motive force, the protons flow back and energy liberated during this backflow of protons activate ATPase present in F1 head to synthesise ATP.
