Question
An example of the competitive inhibition of an enzyme is the inhibition of
Succinic dehydrogenase by malonic acid
Cytochrome oxidase by cyanide
Hexokinase by glucose-6-phosphate
Carbonic anhydrase by carbon dioxide
Solution
A.
Succinic dehydrogenase by malonic acid
Classical example of competitive inhibition is reduction of activity of succinate dehydrogenase by malonate, oxaloacetate and other anions. In competitive inhibition, a competitive inhibitor which has the resemblance with substrate molecule, competes with the substrate for the active site of an enzyme. While the inhibitor (1) occupies the active site, it prevents binding of the substrate to the enzyme.
