Question
Amino acid serine, aspartic acid and phenylalanine are present on the active site of an enzyme. Explain which forces may be involved in bonding the drug to the enzyme if the drug inhibits the holding of the substrate on the active site of the enzyme.
Solution
When amino acids serine is present nearly the substrate held on active site, then its -OH group is free to act as a nucleophile in the enzyme catalysed the reaction. Similarly, if amino acid histidine is present nearly the substrate held on active site, it can catalyse the acid-base reaction because it can take up a proton and can also lose a proton.
