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Biomolecules

Question
CBSEENCH12009638

Which bonds in the backbone of a peptide can rotate freely and which cannot? Give reasons.

Solution
The rotation is not allowed in the peptide bond. The free rotation of a peptide chain can only occur around the bonds joining the nearly planar amide groups to the α-carbons. The free rotation about the peptide bond is respected due to the partial double bond character of the C—N bond in peptide linkage. Therefore, —CONH—group is planar and rigid.